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Teratogenicity of valproic acid: In vivo and in vitro investigations

✍ Scribed by J. Kao; N. A. Brown; B. Schmid; E. H. Goulding; S. Fabro

Book ID: 112213140
Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 961 KB
Volume: 1
Category: Article
ISSN: 0270-3211
DOI: 10.1002/tcm.1770010405

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## Abstract **BACKGROUND:** The antiepileptic drug valproic acid (VPA) is well known to cause neural tube and skeletal defects in both humans and animals. The amidic VPA analogues valpromide (VPD) and valnoctamide (VCD) have much lower teratogenicity than VPA inducing exencephaly in mice. The objec