Valproic acid-induced placental and teratogenic effects in rats
โ Scribed by Khera, K. S.
- Book ID
- 112219319
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 763 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0040-3709
No coin nor oath required. For personal study only.
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Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1