𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Lack of teratogenicity oftrans-2-ene-valproic acid compared to valproic acid in rats

✍ Scribed by Vorhees, Charles V. ;Acuff-Smith, Karen D. ;Weisenburger, Walter P. ;Minck, Daniel R. ;Berry, James S. ;Setchell, Kenneth D. R. ;Nau, Heinz

Book ID
112219194
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
576 KB
Volume
43
Category
Article
ISSN
0040-3709

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Behavioral teratogenicity of valproic ac
Behavioral teratogenicity of valproic acid: selective effects on behavior after prenatal exposure to rats
✍ C. V. Vorhees πŸ“‚ Article πŸ“… 1987 πŸ› Springer 🌐 English βš– 810 KB

Pregnant Sprague-Dawley rats were treated with 0, 150 or 200 mg/kg valproic acid by gavage (VPA) on days 7-18 of gestation. These doses produced no maternal toxicity, reproductive effects or effects on offspring growth and survival. Maternal plasma VPA peak levels averaged 99 and 134 micrograms/ml 1

Pharmacokinetic aspects of drug effects
Pharmacokinetic aspects of drug effects in vitro: effects of serum protein binding on concentration and teratogenicity of valproic acid and 2-en-valproic acid in whole embryos in culture
✍ Constanze Lewandowski; Stephan Klug; Heinz Nau; Diether Neubert πŸ“‚ Article πŸ“… 1986 πŸ› Springer-Verlag 🌐 English βš– 369 KB

Pharmacokinetic studies were performed in connection with culture experiments. Using the technique of cultivating whole rat embryos of the early postimplantation stage, we measured the concentration of valproic acid (VPA) and 2-en-VPA in the culture medium (free and protein-bound form) and in embryo