Teratogenic evaluation of di-n-butyl phthalate in rats
β Scribed by Makoto Ema, ; Hiro Amano, ; Takafumi Itami, ; Hironoshin Kawasaki,
- Book ID
- 122056990
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 563 KB
- Volume
- 69
- Category
- Article
- ISSN
- 0378-4274
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The teratogenicity of butyl benzyl phthalate (BBP) was studied in Wistar rats. Pregnant rats were given BBP at a dosage of 0, 0.25, 0.5, 1.0 or 2.0% in the diet from day 0 to day 20 of pregnancy. Daily intakes of BBP were 185 mg kg-' for the 0.25% group, 375 mg kg-' for the 0.5% group, 654 mg kg-' f
## Abstract Pregnant Wistar rats were given butyl benzyl phthalate (BBP) at a dose of 2.0% in the diet on days 0β20, days 0β11 or days 11β20 of pregnancy. Food consumption and body weight gain were decreased in pregnant rats given BBP. Preβimplantation loss in the BBPβtreated groups was comparable