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Teratogenic evaluation of di-n-butyl phthalate in rats

✍ Scribed by Makoto Ema, ; Hiro Amano, ; Takafumi Itami, ; Hironoshin Kawasaki,


Book ID
122056990
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
563 KB
Volume
69
Category
Article
ISSN
0378-4274

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Evaluation of the teratogenic potential
✍ Makoto Ema; Toshimi Murai; Takafumi Itami; Hironoshin Kawasaki πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 485 KB

The teratogenicity of butyl benzyl phthalate (BBP) was studied in Wistar rats. Pregnant rats were given BBP at a dosage of 0, 0.25, 0.5, 1.0 or 2.0% in the diet from day 0 to day 20 of pregnancy. Daily intakes of BBP were 185 mg kg-' for the 0.25% group, 375 mg kg-' for the 0.5% group, 654 mg kg-' f

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✍ Makoto Ema; Takafumi Itami; Hironoshin Kawasaki πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 442 KB

## Abstract Pregnant Wistar rats were given butyl benzyl phthalate (BBP) at a dose of 2.0% in the diet on days 0–20, days 0–11 or days 11–20 of pregnancy. Food consumption and body weight gain were decreased in pregnant rats given BBP. Pre‐implantation loss in the BBP‐treated groups was comparable