Comparative developmental toxicity ofn-butyl benzyl phthalate and di-n-butyl phthalate in rats
β Scribed by M. Ema; R. Kurosaka; H. Amano; Y. Ogawa
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 550 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0090-4341
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The objective of the present study was to determine if periods of exposure would modify the developmental toxicity of butyl benzyl phthalate (BBP). Pregnant Wistar rats were given BBP at a dose of 2.0% in the diet on days 0-20, days 0-7, days 7-16 or days 16-20 of pregnancy. Food consumption and bod
## Abstract Pregnant Wistar rats were given butyl benzyl phthalate (BBP) at a dose of 2.0% in the diet on days 0β20, days 0β11 or days 11β20 of pregnancy. Food consumption and body weight gain were decreased in pregnant rats given BBP. Preβimplantation loss in the BBPβtreated groups was comparable
The objective of this study was to determine the susceptible day for the developmental toxicity of din-butyl phthalate (DBP). Pregnant rats were given a single dose of DBP by gastric intubation at 1500 mg kg Ψ1 on one of days 6-16 of pregnancy. A significant increase in the incidence of postimplanta
The objective of this study was to determine the susceptible day for the developmental toxicity of butyl benzyl phthalate (BBP) by a single administration on one of the days during organogenesis. Pregnant rats were given a single dose of BBP by gastric intubation at a dose of 1000 mg kg(-1) on one o