Temperature-sensitive mutant of avian erythroblastosis virus suggests a block of differentiation as mechanism of leukaemogenesis
โ Scribed by Graf, Thomas; Ade, Norbert; Beug, Hartmut
- Book ID
- 118674588
- Publisher
- Nature Publishing Group
- Year
- 1978
- Tongue
- English
- Weight
- 695 KB
- Volume
- 275
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/275496a0
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## Abstract Hamster cells (BHK21/13) transformed at the permissive temperature by a temperatureโsensitive mutant (FU 19) of the SchmidtโRuppin strain of Rous sarcoma virus exhibited a temperatureโdependent expression of virusโinduced surface antigen (VISA) as assayed by mixed haemadsorption test. T
Abbreviations: ECM, extracellular matrix; SV40, simian virus 40; a-SMA, a-smooth cells were isolated from a single animal to develop homogeneous muscle actin; TGF-b1, transforming growth factor b1; PCR, polymerase chain reaction.