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Temperature-Dependent Properties of Cells Transformed by a Thermosensitive Mutant of Polyoma Virus

โœ Scribed by Renato Dulbecco and Walter Eckhart

Book ID
123650131
Publisher
National Academy of Sciences
Year
1970
Tongue
English
Weight
311 KB
Volume
67
Category
Article
ISSN
0027-8424

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## Abstract The properties of 121โ€6 cells were characterized. This cell line is transformed by tsโ€121, a temperatureโ€sensitive mutant of polyoma virus. Both the morphology and saturation density of the 121โ€6 cells were affected by temperature; i.e. at 39ยฐ C, the cells grew to monolayer sheets and r

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## Abstract Change in division capability as a phenotypic expression of cellular transformation was investigated by using one of the temperatureโ€sensitive (ts) mutants of the polyoma virusโ€transformed cell line, the 121โ€6โ€5 cells of BALB/3T3. When contact โ€inhibited cells were treated with hyaluron