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Telomeres and telomerases as drug targets

✍ Scribed by Evonne M Rezler; David J Bearss; Laurence H Hurley


Book ID
117786548
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
241 KB
Volume
2
Category
Article
ISSN
1471-4892

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Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be exp