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Telomeres and telomerase as targets for cancer therapy

✍ Scribed by S. Zimmermann; U. M. Martens

Book ID: 111706556
Publisher: Springer
Year: 2007
Tongue: English
Weight: 487 KB
Volume: 64
Category: Article
ISSN: 1420-682X
DOI: 10.1007/s00018-007-6481-8

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Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be exp