Telomere and Telomerase as Targets for Cancer Therapy
โ Scribed by Xiaoping Tian; Bo Chen; Xiaochuan Liu
- Book ID
- 107565321
- Publisher
- Springer-Verlag
- Year
- 2009
- Tongue
- English
- Weight
- 333 KB
- Volume
- 160
- Category
- Article
- ISSN
- 0273-2289
No coin nor oath required. For personal study only.
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Telomeres are guanine-rich regions that are located at the ends of chromosomes and are essential for preventing aberrant recombination and protecting against exonucleolytic DNA degradation. Telomeres are maintained by telomerase, an RNA-dependent DNA polymerase. Because telomerase is known to be exp
Telomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chromosomes. The enzyme telomerase is one mechanism that maintains telomeres, and is activated in 85% of human cancer cells. New studies on peptide nucleic acids (PNAs) that inhibit telomerase have demonstrated t