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Telomerase as a possible target for anticancer therapy

✍ Scribed by Chantal Autexier

Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
68 KB
Volume
6
Category
Article
ISSN
1074-5521

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✦ Synopsis

Telomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chromosomes. The enzyme telomerase is one mechanism that maintains telomeres, and is activated in 85% of human cancer cells. New studies on peptide nucleic acids (PNAs) that inhibit telomerase have demonstrated that unexpected regions of the enzyme can serve as targets for inhibitors. The novel delivery method used expands the utility of PNAs.

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