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Telomere dysfunction and genome instability

✍ Scribed by Frias, Cristina

Book ID: 111643131
Publisher: Frontiers in BioScience
Year: 2012
Tongue: English
Weight: 968 KB
Volume: 17
Category: Article
ISSN: 1093-9946
DOI: 10.2741/4044

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## Abstract The development of genomic instability is an important step toward generating the multiple genetic changes required for cancer. Telomere dysfunction is one of the factors that contribute to tumorigenesis. Telomeres shorten with each cell division in the absence of telomerase. Human mamm