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Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis

โœ Scribed by Hackett, Jennifer A; Greider, Carol W


Book ID
110066284
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
261 KB
Volume
21
Category
Article
ISSN
0950-9232

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Telomeres and telomerase: A dual role in
โœ Ande Satyanarayana; Michael P. Manns; K. Lenhard Rudolph ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 201 KB

Telomere shortening limits the proliferative capacity of primary human cells and restrains the regenerative capacity of organ systems during chronic diseases and aging. Telomere shortening apparently has a dual role in tumor development and progression. On the one hand, it induces chromosomal instab