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Telomeres: protecting chromosomes against genome instability

✍ Scribed by O'Sullivan, Roderick J.; Karlseder, Jan


Book ID
109959320
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
747 KB
Volume
11
Category
Article
ISSN
1471-0072

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## Abstract Telomere shortening and chromosomal instability are believed to play an important role in the development of myeloid neoplasia. So far, published data are only available on the average telomere length in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), but not on the te

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## Abstract The development of genomic instability is an important step toward generating the multiple genetic changes required for cancer. Telomere dysfunction is one of the factors that contribute to tumorigenesis. Telomeres shorten with each cell division in the absence of telomerase. Human mamm