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Telomerase expression and p53 status in hepatocellular carcinoma

โœ Scribed by Takashi Kobayashi; Yasuhiko Sugawara; Ya-Zhou Shi; Masatoshi Makuuchi

Book ID
119393735
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
62 KB
Volume
97
Category
Article
ISSN
0002-9270

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The cyclin-dependent kinase inhibitor p21/WAF1 is regulated by p53-dependent and p53-independent pathways. In addition, p21/WAF1 binds with proliferating cell nuclear antigen (PCNA) and inhibits the action of PCNA. To investigate the possible role of p21/WAF1 in human hepatocellular carcinomas (HCCs