The cyclin-dependent kinase inhibitor p21/WAF1 is regulated by p53-dependent and p53-independent pathways. In addition, p21/WAF1 binds with proliferating cell nuclear antigen (PCNA) and inhibits the action of PCNA. To investigate the possible role of p21/WAF1 in human hepatocellular carcinomas (HCCs
โฆ LIBER โฆ
p53 gene mutation and COX-2 expression in hepatocellular carcinoma
โ Scribed by Moon-Il Park; Song-Yi Choi; Sun-Young Na; Dae Young Kang
- Book ID
- 118078409
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2009
- Tongue
- English
- Weight
- 469 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1755-9294
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BACKGROUND. Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts of the world, but to the authors' knowledge to date the status of this gene has not been studied in HCC patients in India, where HCC is one of the major cancers and