Telomerase: Composition, Functions and Clinical Implications : Composition, Functions and Clinical Implications

✍ Scribed by Aiden N. Gagnon

Publisher: Nova Science Publishers, Incorporated
Year: 2010
Tongue: English
Leaves: 172
Series: DNA: Properties and Modifications, Functions and Interactions, Recombination and Applications
Edition: 1
Category: Library

No coin nor oath required. For personal study only.

✦ Synopsis

Telomerase is a ribonucleoprotein enzyme that catalyzes the cellular synthesis of telomeric DNA during cellular division, resulting in maintenance of telomere length and increased proliferative potential. Several studies suggest that the telomerase may play an important role in the diagnosis and prognosis of cancer because its expression strongly correlates with the potential tumor progression. Ninety percent of human cancers on different organs have shown high telomerasa activity. This book reviews research in the field of telomerase including functions of telomerase independent of its interaction with telomeres on gene expression and chromatin structure; histone deacetylase inhibition as an anticancer telomerase-targeting strategy and others.

✦ Subjects

Telomerase.

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