β Scribed by Harold Papkoff (auth.), Joyce W. Lustbader Ph.D., David Puett Ph.D., Raymond W. Ruddon M.D., Ph.D. (eds.)
No coin nor oath required. For personal study only.
Advances in the field of glycoprotein hormones necessitated a second international symposium on this topic, held March 11 to 14, 1993, in Santa Barbara, California, and again sponsored by Serono Symposia, USA. The meeting was twofold in its concept: (1) the dissemination of the current research in the field and (2) honoring three scientists who have greatly contributed to this field, Drs. Harold Papkoff, Robert Ryan, and Darrell Ward, upon their retirements. We were honored to have Dr. John Pierre present as a participant at the meeting and also serving as master of ceremonies at the banquet. Certainly one of the highlights at the first meeting, held in 1989, was the cloning of the CG/LH receptor. This second meeting was also filled with insightful and innovative scientific presentations. Significant advances in the regulation of gene transcription of the gonadotropins were presented by Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. These presentations reflected major advances from the in the understanding concepts offered at the last meeting. Other advances of hormone structure/function included the continuing work by Joyce Lustbader on the determination of the three-dimensional structure of hCG, including a new approach using nonisotopic labels for 3-D and 4-D NMR imaging. New insights into biosynthesis of hCG were proposed by Irving Boime. Studies directed at identifying receptor contact regions were presented by Henry Keutmann and David Puett.
Front Matter....Pages i-xx
Front Matter....Pages 1-1
Reflections on Purifying Gonadotropins in the 1960s....Pages 3-7
Where to from Here?....Pages 8-10
Remembrance of Things Foregone....Pages 11-15
Front Matter....Pages 17-17
Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Mice....Pages 19-35
Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta....Pages 36-43
Role of Helix-Loop-Helix Proteins in Gonadotropin Gene Expression....Pages 44-64
Cyclic AMP-Mediated Hormonal Regulation of Gene Transcription....Pages 65-74
Regulation and Expression of Thyroid Stimulating Hormone....Pages 75-78
Front Matter....Pages 79-79
Human Chorionic Gonadotropin: Progress in Determining Its Tertiary Structure....Pages 81-102
Receptor Binding Regions of hLH and hCGΞ²-Subunit: Structural and Functional Properties....Pages 103-117
Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin Ξ² Gene Cluster....Pages 118-121
Delineation of Subunit and Receptor Contact Sites by Site-Directed Mutagenesis of hCGΞ²....Pages 122-134
Front Matter....Pages 135-135
Folding of the Ξ²-Subunit of hCG and Its Role in Assembly of the Ξ±-Ξ² Heterodimer....Pages 137-155
Structure and Function of the Gonadotropin Free Ξ± Molecule of Pregnancy....Pages 156-166
Glycosylation and Glycoprotein Hormone Function....Pages 167-174
Front Matter....Pages 175-175
Structure and Regulated Expression of the TSH Receptor Gene: Differences and Similarities to Gonadotropin Receptors....Pages 177-216
Studies on the Structure and Function of Gonadotropins....Pages 217-225
Hormone Binding and Activation of the LH/CG Receptor....Pages 226-249
Front Matter....Pages 251-251
Use of the Free Alpha Subunit (FAS) of Glycoprotein Secreting Hormones as a Surrogate Marker of GnRH Secretion in the Human....Pages 253-263
Free hCGΞ² and Nongonadal Neoplasms....Pages 264-280
Front Matter....Pages 251-251
New Clinical Applications of hCG Assays....Pages 281-292
Ξ²-Core Fragment: Structure, Production, Metabolism, and Clinical Utility....Pages 293-320
Human Pituitary Chorionic Gonadotropin Is Produced, Circulated, and Excreted in Multiple Isoforms....Pages 321-342
Thyrotropin Abnormalities in Central Hypothyroidism....Pages 343-348
Back Matter....Pages 349-381
Cell Biology
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