Heparin: Structure, Function, and Clinical Implications

✍ Scribed by Roger W. Jeanloz (auth.), Ralph A. Bradshaw, Stanford Wessler (eds.)

• Publisher: Springer US
• Year: 1975
• Tongue: English
• Leaves: 410
• Series: Advances in Experimental Medicine and Biology 52
• Edition: 1
• Category: Library

✦ Synopsis

The International Symposium on Heparin, held May 13-15, 1974, in St. Louis, Missouri, as a part of the dedication of the Shoenberg Pavilion of the Jewish Hospital of St. Louis, was conceived as a forum to bring together physicians and scientists with a basic in­ terest in the structure, function and clinical usefulness of heparin. Few naturally occurring substances have commanded the breadth of interest among members of the biomedical research community as this compound has. Aspects of its covalent and three-dimensional struc­ ture, its biosynthesis, its interaction with and effect on physio­ logically important moieties and its use as a therapeutic agent in a variety of disease states have been actively studied for the past several decades. Thus, the present state of these studies seemed to be a timely subject for discussion, not only to gather together in one place representative samples of the myriad of data on heparin but also to underscore the ever increasing necessity for communica­ tion between basic research and clinical practice.

✦ Table of Contents

Front Matter....Pages i-x
Front Matter....Pages 1-1
The Chemistry of Heparin....Pages 3-17
Crystalline Structure of Heparin....Pages 19-37
Three-Dimensional Model of Heparin....Pages 39-49
Heparin and Heparin-Like Substances of Cells....Pages 51-60
Biosynthesis of Heparin....Pages 61-77
Metabolism of Macromolecular Heparin in Murine Neoplastic Mast Cells....Pages 79-83
Demonstration of Endogenous Heparin in Rat Blood....Pages 85-93
Relation of Chemical Structure of Heparin to Its Anticoagulant Activity....Pages 95-103
Synthesis and Properties of Heparin Derivatives....Pages 105-118
Low-Molecular-Weight Derivative of Heparin that is Orally Active in Mice....Pages 119-130
Heparin is an Anionic Hydrated Anticoagulant....Pages 131-137
What is “Heparin”?....Pages 139-147
Determination of Heparin in Small Tissue Samples....Pages 149-154
Identification and Quantification of Tissue Heparin by Microelectrophoresis: A Critique....Pages 155-162
Standards for Heparin....Pages 163-179
Application of the Kinetics of Heparin to the Formulation of Dosage Schedules....Pages 181-192
Front Matter....Pages 193-193
Antithrombin III: A Backward Glance O’Er Travel’d Roads....Pages 195-215
The Coagulation-Fibrinolytic Mechanism and the Action of Heparin....Pages 217-238
Heparin Interaction with Activated Factor X and Its Inhibitor....Pages 239-242
Evidence of a Catalytic Role of Heparin in Anticoagulation Reactions....Pages 243-247
Front Matter....Pages 193-193
Structural and Functional Relationships of Human Antithrombin III and Alpha 1 -Antitrypsin....Pages 249-253
Heparin, Lysolecithin, and Platelet Function....Pages 255-261
Effect of Lung and Gut Heparin on Experimental Arterial Thrombosis....Pages 263-268
Lipoprotein Lipase....Pages 269-279
“Lipolipin”: A Glycoprotein Inhibitor of Postheparin Plasma Lipoprotein Lipase....Pages 281-288
Heparin as an Inhibitor of Mammalian Protein Synthesis....Pages 289-297
The Effect of Heparin on Oxygen Transport from Blood to Tissues....Pages 299-306
Front Matter....Pages 307-307
Clinical Implications of Heparin....Pages 309-322
Low-Dose Heparin in the Prevention of Venous Thromboembolism — Rationale and Results....Pages 323-340
Long-Term Use of Minidose Heparin in Post-Myocardial Infarction....Pages 341-350
Wall-Bonded Heparin — Historical Background and Current Clinical Applications....Pages 351-363
Surface-Bonded Heparin....Pages 365-374
Heparin-Induced Osteopenia: An Appraisal....Pages 375-387
The Use of Heparin as an Anti-Thrombotic Agent: A Panel Discussion....Pages 389-409
Back Matter....Pages 411-422

✦ Subjects

Cardiology