TEL-AML1 positivity in relapsed B cell precursor acute lymphoblastic leukemia in childhood
✍ Scribed by Seeger, K; Buchwald, D; Taube, T; Peter, A; von Stackelberg, A; Schmitt, G; Köchling, J; Henze, G
- Book ID
- 110054293
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 71 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0887-6924
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📜 SIMILAR VOLUMES
Acute lymphoblastic leukemia (ALL) is the most common form of childhood cancer. The peak incidence of ALL between ages 2 and 5 is accounted for by one subtype, referred to as common acute lymphoblastic leukemia (cALL). About 25% of cALL patients have the TEL-AML1 gene fusion derived from the t(12;21
## Abstract The __TEL/AML1__ rearrangement has been implicated as an independent good prognostic factor in pediatric acute lymphoblastic leukemia (ALL). We examined __TEL/AML1__ using nested reverse‐transcription polymerase chain reaction (RT‐PCR) and correlated __TEL/AML1__ with cytogenetics and i