Taurine release from brain slices in thioacetamide-induced hepatic encephalopathy in rats
β Scribed by Urszula Wysmyk; Simo S. Oja; Pirjo Saransaari
- Publisher
- Springer-Verlag
- Year
- 1991
- Tongue
- English
- Weight
- 684 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1044-7393
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## Abstract Increased ammonia is a major pathogenic factor in hepatic encephalopathy (HE), a neurologic syndrome associated with glutamatergic dysfunction. Previous studies have shown that in rat cerebral cortical slices or a gliaβderived cell line, acute treatment with ammonia in vitro and in vivo
Crude (P2) synaptosomes derived from rats with acute hepatic encephalopathy (HE) induced with thioacetamide showed a slightly increased uptake of radiolabeled arginine (ARC) and a 2.5-fold enhanced conversion of newly taken-up ARC to both glutamate (GLU) and y-aminobutyric acid (GABA) as compared wi
Functional changes of various neurotransmitter systems have been implicated in the pathogenesis of hepatic encephalopathy. In this study the role of brain monoaminergic neurotransmitter systems in hepatic encephalopathy was investigated in rats with thioacetamide-induced acute liver failure. Concent