A new linker for the synthesis of C-term
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Jean-Sébastien Fruchart; Hélène Gras-Masse; Oleg Melnyk
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Article
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1999
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Elsevier Science
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French
⚖ 268 KB
A tartaric acid-based linker was elaborated on an amino PEGA resin for the synthesis of C-terminal cx-oxoaldehydes. A solid phase periodic oxidation allowed the formation of the glyoxylyl moiety and the separation of the final product from the solid support.