Targeting the T cell receptor in rheumatoid arthritis
โ Scribed by Brian L. Kotzin; John Kappler
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 627 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Objective: To examine whether the t cell receptor (tcr) a or tcrb loci exhibit linkage with disease in multiplex rheumatoid arthritis (ra) families. ## Methods: A linkage study was performed in 184 ra families from the uk arthritis and rheumatism council repository, each containing at least 1
The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLAassociated risk, although alleles at ot