HLA and T Cell Receptor Polymorphisms in Pauciarticular-Onset Juvenile Rheumatoid Arthritis

✍ Scribed by Barbara S. Nepom; Uma Malhotra; David A. Schwarz; James W. Nettles; Jane G. Schaller; Patrick Concannon

• Publisher: John Wiley and Sons
• Year: 1991
• Tongue: English
• Weight: 755 KB
• Volume: 34
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780341009

✦ Synopsis

The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLAassociated risk, although alleles at other loci contribute independently. A candidate disease-associated T cell receptor polymorphism, in contrast, was not identified in this population. Mechanistic implications of these findings are discussed.

Pauciarticular-onset juvenile rheumatoid arthritis (JRA) is the most common form of JRA, characterized by clinically important articular and ophthalmologic manifestations. It typically affects females, beginning during the first few years of life, with