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HLA and T cell receptor β-chain DNA polymorphisms identify a distinct subset of patients with pauciarticular-onset juvenile rheumatoid arthritis

✍ Scribed by Patrick Charmley; Barbara S. Nepom; Patrick Concannon

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
671 KB
Volume
37
Category
Article
ISSN
0004-3591

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HLA and T Cell Receptor Polymorphisms in Pauciarticular-Onset Juvenile Rheumatoid Arthritis
✍ Barbara S. Nepom; Uma Malhotra; David A. Schwarz; James W. Nettles; Jane G. Scha 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 755 KB

The immunogenetic basis of pauciarticular-onset juvenile rheumatoid arthritis is unclear. We therefore analyzed the HLA and T cell receptor genes present in a clinically well-defined group of patients. We found that the DR8 haplotype contributes most of the HLAassociated risk, although alleles at ot