Targeting the subthalamic nucleus in the treatment of Parkinson’s disease
✍ Scribed by J.M Henderson; S.B Dunnett
- Book ID
- 117502629
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 210 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0361-9230
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## Abstract Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN s
The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded t