✦ LIBER ✦

The subthalamic nucleus: A possible target for stereotaxic surgery in parkinson's disease

✍ Scribed by J. Guridi; M. R. Luquin; M. T. Herrero; Dr. J. A. Obeso

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 902 KB
Volume: 8
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.870080402

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism. We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.

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