Network modulation by the subthalamic nucleus in the treatment of Parkinson's disease
✍ Scribed by Maja Trošt; Sherwin Su; Philip Su; Ruoh-Fang Yen; Ham-Min Tseng; Anna Barnes; Yilong Ma; David Eidelberg
- Book ID
- 118489736
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 274 KB
- Volume
- 31
- Category
- Article
- ISSN
- 1053-8119
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The role of the subthalamic nucleus (STN) in the origin of parkinsonian tremor is discussed. Previous studies in monkeys made parkinsonian by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) administration suggested a direct participation of the STN in the pathophysiology of tremor. We recorded t
Microelectrode recordings of single unit neuronal activity were used during stereotactic surgery to define the subthalamic nucleus for chronic deep brain stimulation in the treatment of Parkinson's disease. By using five parallel trajectories, often two to three microelectrodes allow us to recognize