A role for the pregnane X receptor in fl
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Elise Andrews; Martin Armstrong; Jonathan Tugwood; Dan Swan; Philip Glaves; Muni
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Article
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2010
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John Wiley and Sons
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English
โ 224 KB
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Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment. There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify gene