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The protective role of pregnane X receptor in lipopolysaccharide/D-galactosamine-induced acute liver injury

✍ Scribed by Wang, Kun; Damjanov, Ivan; Wan, Yu-Jui Yvonne


Book ID
109885316
Publisher
Nature Publishing Group
Year
2009
Tongue
English
Weight
536 KB
Volume
90
Category
Article
ISSN
0023-6837

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Drug-induced liver injury (DILI) due to flucloxacillin is a rare but serious complication of treatment. There is some evidence that flucloxacillin is a human pregnane X receptor (PXR) agonist. This study was designed to investigate the relevance of PXR to flucloxacillin toxicity and to identify gene