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Targeting for insulin-like growth factor-I receptor with short hairpin RNA for human digestive/gastrointestinal cancers

✍ Scribed by Yu Wang; Yasushi Adachi; Arisa Imsumran; Hiroyuki Yamamoto; Wenhua Piao; Hua Li; Masanori Ii; Yoshiaki Arimura; Mi Young Park; Dalrae Kim; Choon-Taek Lee; David P. Carbone; Kohzoh Imai; Yasuhisa Shinomura


Book ID
106180576
Publisher
Springer Japan
Year
2009
Tongue
English
Weight
643 KB
Volume
45
Category
Article
ISSN
0944-1174

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We report the amplification and overexpression of the IGFlR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band I5q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unseleaed tumor series to more than 10% in breast cancers with hs