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The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer

✍ Scribed by Anna Almeida; Martine Muleris; Bernard Dutrillaux; Bernard Malfoy

Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 264 KB
Volume: 11
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870110110

No coin nor oath required. For personal study only.

✦ Synopsis

We report the amplification and overexpression of the IGFlR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band I5q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unseleaed tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression. Genes Chromosom Cancer I /:63-65 (1994).

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