Targeting Chronic Myeloid Leukemia Stem Cells
β Scribed by G. Vignir Helgason; Graham A. R. Young; Tessa L. Holyoake
- Book ID
- 107540266
- Publisher
- Current Science Inc.
- Year
- 2010
- Tongue
- English
- Weight
- 221 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1558-8211
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In this article, the rationale for autografting in chronic myeloid leukemia is reviewed, and alternative therapeutic approaches to the use of granulocyte-colony stimulating factor and chemotherapymobilized peripheral blood stem cells are discussed. The data from patients treated using the original I
Various clinical observations have implicated T cells in the control of chronic myeloid leukemia (CML). These observations have in recent years been supported by laboratory results indicating the presence of CML-specific T cells in the lymphocyte repertoire of both normal healthy individuals and dis
## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcrβabl__ oncogene. The BCRβABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func