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Global dynamics of hematopoietic stem cells and differentiated cells in a chronic myeloid leukemia model

✍ Scribed by Bedr’Eddine Aïnseba; Chahrazed Benosman

Publisher
Springer
Year
2010
Tongue
English
Weight
713 KB
Volume
62
Category
Article
ISSN
0303-6812

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## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcr‐abl__ oncogene. The BCR‐ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func