## Abstract Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the __bcrβabl__ oncogene. The BCRβABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell func
Characterization of chronic myeloid leukemia stem cells
β Scribed by Jonathan M. Gerber; Lu Qin; Jeanne Kowalski; B. Douglas Smith; Constance A. Griffin; Milada S. Vala; Michael I. Collector; Brandy Perkins; Marianna Zahurak; William Matsui; Christopher D. Gocke; Saul J. Sharkis; Hyam I. Levitsky; Richard J. Jones
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 691 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0361-8609
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In two patients with blastic transformation of chronic myeloid leukemia complete remission was induced, but meningeal leukemia subsequently developed. The recognition of blast cell crisis a s the presenting feature of chronic myeloid leukemia is discussed, together with treatment of this condition a
Fig. 1. Axial MRI showing many lesions in both hemispheres. High-Disseminated Aspergillosis After Mobilization With intensity signal on T2, with a moderate surrounding edema and Intensive Chemotherapy Prior to Autologous Stem-Cell effect of mass. ## Transplant in Chronic Myeloid Leukemia To the E