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Meningeal leukemia after blastic transformation of chronic myeloid leukemia

✍ Scribed by K. Atkinson; H. E. M. Kay; Sylvia D. Lawler; D. G. Wells; T. J. McElwain

Publisher
John Wiley and Sons
Year
1975
Tongue
English
Weight
443 KB
Volume
35
Category
Article
ISSN
0008-543X

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✦ Synopsis

In two patients with blastic transformation of chronic myeloid leukemia complete remission was induced, but meningeal leukemia subsequently developed. The recognition of blast cell crisis a s the presenting feature of chronic myeloid leukemia is discussed, together with treatment of this condition and its rare complication, meningeal leukemia. The development of meningeal leukemia in this disease is almost certainly due to the increased survival that has been produced by advances in therapy for blastic transformation.

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A spontaneous oscillation of the peripheral-blood leukocyte count was observed in a 7-year-old girl with chronic granulocytic leukemia in blastic crisis. The time interval between nadir and nadir of approximately 2 months was similar t o that found in other patients with CGL studied prospectively du