Spontaneous leukocyte oscillation during blastic crisis of chronic myeloid leukemia

✍ Scribed by Professor Renato Mastrangelo; Achille Stabile; Dante Parenti; Giuseppe Segnis

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 399 KB
• Volume: 33
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(197406)33:6<1610::aid-cncr2820330621>3.0.co;2-b

✦ Synopsis

A spontaneous oscillation of the peripheral-blood leukocyte count was observed in a 7-year-old girl with chronic granulocytic leukemia in blastic crisis. The time interval between nadir and nadir of approximately 2 months was similar t o that found in other patients with CGL studied prospectively during the chronic phase of the disease. T h e spontaneous fluctuation of the ultimately prevailing blastic stem line is consistent with the view that the leukemic cells of the blastic crisis may not be fully autonomous. Implications regarding pathogenesis a n d therapy of the blastic crisis are discussed.