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Targeting ALT: The role of alternative lengthening of telomeres in pathogenesis and prevention of cancer

✍ Scribed by F. Mathias Bollmann

Book ID
116395163
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
145 KB
Volume
33
Category
Article
ISSN
0305-7372

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## Abstract Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In ∼85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are th