Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes
β Scribed by Christopher M. Heaphy; Andrea P. Subhawong; Seung-Mo Hong; Michael G. Goggins; Elizabeth A. Montgomery; Edward Gabrielson; George J. Netto; Jonathan I. Epstein; Tamara L. Lotan; William H. Westra; Ie-Ming Shih; Christine A. Iacobuzio-Donahue; Anirban Maitra; Qing K. Li; Charles G. Eberhart; Janis M. Taube; Dinesh Rakheja; Robert J. Kurman; T.C. Wu; Richard B. Roden; Pedram Argani; Angelo M. De Marzo; Luigi Terracciano; Michael Torbenson; Alan K. Meeker
- Book ID
- 116203361
- Publisher
- American Society for Investigative Pathology
- Year
- 2011
- Tongue
- English
- Weight
- 730 KB
- Volume
- 179
- Category
- Article
- ISSN
- 0002-9440
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## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombinationβbased, alternative lengthening
## Abstract Two types of telomere maintenance mechanisms (TMMs) have been described in human tumors: telomerase activation and alternative lengthening of telomeres (ALT). Although the vast majority of epithelial tumors rely on telomerase activation, many mesenchymal tumors rely on ALT for telomere