Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells
β Scribed by Nabetani, A.; Ishikawa, F.
- Book ID
- 118744652
- Publisher
- Oxford University Press
- Year
- 2010
- Tongue
- English
- Weight
- 371 KB
- Volume
- 149
- Category
- Article
- ISSN
- 0021-924X
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Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates). In most normal human cells, telomeres shorten with each cell division, and it is proposed that this limits the number of times these cells can replicate. Telomeres may be mainta
## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombinationβbased, alternative lengthening
## Abstract Two types of telomere maintenance mechanisms (TMMs) have been described in human tumors: telomerase activation and alternative lengthening of telomeres (ALT). Although the vast majority of epithelial tumors rely on telomerase activation, many mesenchymal tumors rely on ALT for telomere