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Alternative lengthening of telomeres pathway: Recombination-mediated telomere maintenance mechanism in human cells

✍ Scribed by Nabetani, A.; Ishikawa, F.


Book ID
118744652
Publisher
Oxford University Press
Year
2010
Tongue
English
Weight
371 KB
Volume
149
Category
Article
ISSN
0021-924X

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Telomeres of eukaryotic chromosomes contain many tandem repeats of a G-rich sequence (for example, TTAGGG in vertebrates). In most normal human cells, telomeres shorten with each cell division, and it is proposed that this limits the number of times these cells can replicate. Telomeres may be mainta

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## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombination‐based, alternative lengthening

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