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Alternative lengthening of telomeres in mammalian cells

✍ Scribed by Henson, Jeremy D; Neumann, Axel A; Yeager, Thomas R; Reddel, Roger R

Book ID: 110066281
Publisher: Nature Publishing Group
Year: 2002
Tongue: English
Weight: 806 KB
Volume: 21
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1205058

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## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombination‐based, alternative lengthening