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Alternative lengthening of telomeres: models, mechanisms and implications

✍ Scribed by Cesare, Anthony J.; Reddel, Roger R.

Book ID
109953173
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
423 KB
Volume
11
Category
Article
ISSN
1471-0056

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## Abstract Unlimited proliferative potential is a hallmark of cancer, and can be achieved through the activation of telomere maintenance mechanisms (TMMs). Most tumors activate telomerase, but a significant minority, mainly of mesenchymal origin, uses a recombination‐based, alternative lengthening