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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

โœ Scribed by Meng, Xiangdong; Noyes, Marcus B; Zhu, Lihua J; Lawson, Nathan D; Wolfe, Scot A

Book ID
109911026
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
489 KB
Volume
26
Category
Article
ISSN
1087-0156

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The ability to achieve site-specific manipulation of the mammalian genome has widespread implications for basic and applied research. Gene targeting is a process in which a DNA molecule introduced into a cell replaces the corresponding chromosomal segment by homologous recombination, and thus presen