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T1ρ-relaxation in articular cartilage: Effects of enzymatic degradation

✍ Scribed by Umamaheswar Duvvuri; Ravinder Reddy; Saurabh D. Patel; Jonathan H. Kaufman; J. Bruce Kneeland; John S. Leigh

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
551 KB
Volume
38
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Spin‐lattice relaxation in the rotating frame (T~1ρ~) dispersion spectroscopy and imaging were used to study normal and enzymatically degraded bovine articular cartilage. Normal specimens demonstrate significant T~1ρ~ “dispersion” (∼60 to ∼130 ms) in the 100 Hz to 9 kHz frequency range. Proteoglycan‐degraded specimens have 33% greater T~1ρ~ values than collagen‐degraded or normal samples. T~1ρ~‐weighted images reveal structure not found in conventional T~1~‐or T~2~‐weighted images. Our results suggest that T~1ρ~ measurements are selectively sensitive to proteoglycan content. The potential of this method in distinguishing the early degenerative changes in cartilage associated with osteoarthritis is discussed.

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