Effect of multislice acquisition on T1 and T2 measurements of articular cartilage at 3T

✍ Scribed by Atsuya Watanabe; Chris Boesch; Takayuki Obata; Suzanne E. Anderson

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 333 KB
• Volume: 26
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.20962

✦ Synopsis

Abstract

Purpose

The aim of this study was to investigate the effect of magnetization transfer on multislice T~1~ and T~2~ measurements of articular cartilage.

Materials and Methods

A set of phantoms with different concentrations of collagen and contrast agent (Gd‐DTPA^2−^) were used for the in vitro study. A total of 20 healthy knees were used for the in vivo study. T~1~ and T~2~ measurements were performed using fast‐spin‐echo inversion‐recovery (FSE‐IR) sequence and multi‐spin‐echo (MSE) sequence, respectively, in both in vitro and in vivo studies. We investigated the difference in T~1~ and T~2~ values between that measured by single‐slice acquisition and that measured by multislice acquisition.

Results

Regarding T~1~ measurement, a large drop of T~1~ in all slices and also a large interslice variation in T~1~ were observed when multislice acquisition was used. Regarding T~2~ measurement, a substantial drop of T~2~ in all slices was observed; however, there was no apparent interslice variation when multislice acquisition was used.

Conclusion

This study demonstrated that the adaptation of multislice acquisition technique for T~1~ measurement using FSE‐IR methodology is difficult and its use for clinical evaluation is problematic. In contrast, multislice acquisition for T~2~ measurement using MSE was clinically applicable if inaccuracies caused by multislice acquisition were taken into account. J. Magn. Reson. Imaging 2007;26:109–117. © 2007 Wiley‐Liss, Inc.