𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Proteoglycan-induced changes in T1ρ-relaxation of articular cartilage at 4T

✍ Scribed by Sarma V.S. Akella; Ravinder Reddy Regatte; Alexander J. Gougoutas; Arijitt Borthakur; Erik M. Shapiro; J. Bruce Kneeland; John S. Leigh; Ravinder Reddy

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
353 KB
Volume
46
Category
Article
ISSN
0740-3194

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Proteoglycan (PG) depletion‐induced changes in T~1ρ~ (spin‐lattice relaxation in rotating frame) relaxation and dispersion in articular cartilage were studied at 4T. Using a spin‐lock cluster pre‐encoded fast spin echo sequence, T~1ρ~ maps of healthy bovine specimens and specimens that were subjected to PG depletion were computed at varying spin‐lock frequencies. Sequential PG depletion was induced by trypsinization of cartilage for varying amounts of time. Results demonstrated that over 50% depletion of PG from bovine articular cartilage resulted in average T~1ρ~ increases from 110–170 ms. Regression analysis of the data showed a strong correlation (R^2^ = 0.987) between changes in PG and T~1ρ~. T~1ρ~ values were highest at the superficial zone and decreased gradually in the middle zone and again showed an increasing trend in the region near the subchondral bone. The potentials of this method in detecting early degenerative changes of cartilage are discussed. Also, T~1ρ~‐dispersion changes as a function of PG depletion are described. Magn Reson Med 46:419–423, 2001. © 2001 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Strain-dependent T1 relaxation profiles
Strain-dependent T1 relaxation profiles in articular cartilage by MRI at microscopic resolutions
✍ Yang Xia; Nian Wang; Jihyun Lee; Farid Badar 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 383 KB

To investigate the dependency of T 1 relaxation on mechanical strain in articular cartilage, quantitative magnetic resonance T 1 imaging experiments were carried out on cartilage before/ after the tissue was immersed in gadolinium contrast agent and when the tissue was being compressed (up to ~48% s

Quantification of T2 relaxation changes
Quantification of T2 relaxation changes in articular cartilage with in situ mechanical loading of the knee
✍ David Nag; Gary P. Liney; Paul Gillespie; Kevin P. Sherman 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB

## Abstract ## Purpose To devise a method for producing in vivo MRI images of the knee under physiologically significant loading, and to compare and evaluate the changes in cartilage characteristics before and during in situ compression of the knee. ## Material and Methods A total of 26 asymptom

T2 relaxation time and delayed gadoliniu
T2 relaxation time and delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) of human patellar cartilage at 1.5 T and 9.4 T: Relationships with tissue mechanical properties
✍ E. Lammentausta; P. Kiviranta; M.J. Nissi; M.S. Laasanen; I. Kiviranta; M.T. Nie 📂 Article 📅 2006 🏛 Elsevier Science 🌐 English ⚖ 241 KB 👁 1 views

## Abstract Quantitative magnetic resonance imaging (MRI) techniques have been developed for noninvasive assessment of the structure of articular cartilage. T~2~ relaxation time is sensitive to the integrity and orientation of the collagen network, while T~1~ relaxation time in presence of Gd‐DTPA^

Changes in the proton T2 relaxation time
Changes in the proton T2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T
✍ Hao Lei; Yi Zhang; Xiao-Hong Zhu; Wei Chen 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 236 KB

## Abstract Proton __T__~2~ relaxation times of cerebral water and metabolites were measured before, during, and after transient forebrain ischemia in rat at 9.4 T using localized proton magnetic resonance spectroscopy (^1^H‐MRS) with Hahn echoes formed at different echo times (TEs). It was found t

Comparison of T1 relaxation times of the
Comparison of T1 relaxation times of the neurochemical profile in rat brain at 9.4 tesla and 14.1 tesla
✍ Cristina Cudalbu; Vladimír Mlynárik; Lijing Xin; Rolf Gruetter 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB

## Abstract Knowledge of __T__~1~ relaxation times can be important for accurate relative and absolute quantification of brain metabolites, for sensitivity optimizations, for characterizing molecular dynamics, and for studying changes induced by various pathological conditions. ^1^H __T__~1~ relaxa