Translocation t( 14; I9)(q32;q 13) is a rare but recurrent abnormatiy in chronic lymphocytic leukemia and small cell lymphoma. It has been associated with rearrangements of the BCU gene, which is located at the breakpoint on chromosome 19 and is juxtaposed to the immunoglobutin heavy chain tocus on
t(14;19)(q32;q13) incidence and significance in B-cell lymphoproliferative disorders
✍ Scribed by R. J. Kelly; D. Wright; K. Patil; M. Chapple; S. S. Jalihal; S. L. Barrans; S. J. M. O’Connor; K. Turner; A. S. Jack; R. G. Owen
- Book ID
- 108675691
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 57 KB
- Volume
- 141
- Category
- Article
- ISSN
- 0007-1048
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The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute
## Abstract The t(14;19)(q32;q13) is a recurrent chromosomal translocation reported in a variety of B‐cell leukemias and lymphomas, including chronic lymphocytic leukemia (CLL). CLL cases associated with t(14;19) often have atypical morphologic and immunophenotypic features and unmutated immunoglob