t(14;19)(q32;q13)-associated B-cell neoplasms—a review
✍ Scribed by Ayoma D. Attygalle
- Book ID
- 118825388
- Publisher
- Springer-Verlag
- Year
- 2011
- Tongue
- English
- Weight
- 342 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1865-5785
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The recurrent t(14;19)(q32;q13) translocation associated with chronic B-cell lymphoproliferative disorders, such as atypical chronic lymphocytic leukemia, results in the juxtaposition of the IGH@ and BCL3 genes and subsequent overexpression of BCL3. We report six patients with B-cell precursor acute
Translocation t( 14; I9)(q32;q 13) is a rare but recurrent abnormatiy in chronic lymphocytic leukemia and small cell lymphoma. It has been associated with rearrangements of the BCU gene, which is located at the breakpoint on chromosome 19 and is juxtaposed to the immunoglobutin heavy chain tocus on