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t(11;18)(q21;q21) is a recurrent chromosome abnormality in small lymphocytic lymphoma

✍ Scribed by Constance A. Griffin; Barbara A. Zehnbauer; Richard Ambinder; William E. Beschorner; Risa Mann

Book ID: 102844548
Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 527 KB
Volume: 4
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870040209

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✦ Synopsis

W e have identified two cases of previously untreated, small lymphocytic lymphoma with extranodal involvement, which had a reciprocal translocation, t( I I ; I8)(q2 I ;q2 I), as the sole cytogenetic abnormality. These two cases are remarkably similar to two previously reported cases carrying this translocation with regard to clinical features, cytogenetic abnormality, histologic subtype, and immunophenotype. Molecular genetic analysis of these two cases revealed clonal gene rearrangement of the IGH locus but only germline configuration of the BCLZ oncogene at I8q2 I when probes and conditions that usually identify BCL2 rearrangement in lymphomas were used. Lymphomas bearing an (I I ; 18) rearrangement appear to make up a phenotypically identifiable subgroup. Identification of the genes at the translocation breakpoints will be important. Genes Chrom Cancer 4: 153-1 5 7 ( / 992).

MATERIALS AND METHODS Clinical History

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