t(11;18)(q21;q21) may delineate a spectrum of diffuse small B-cell lymphoma with extranodal involvement

✍ Scribed by Dominique Leroux; Paule Seité; Josette Hillion; François le Marc'hadour; Brigitte Pégourié-Bandelier; Marie-Christine Jacob; Christian-Jacques Larsen; Jean-Jacques Sotto

• Book ID: 102221202
• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 321 KB
• Volume: 7
• Category: Article
• ISSN: 1045-2257
• DOI: 10.1002/gcc.2870070109

✦ Synopsis

We describe a patient with stage IV non-Hodgkin's lymphoma (NHL) and a t ( I I; I8)(q2I ;q21) translocation. He presented with a gastric small B-cell lymphocytic lymphoma, expressing lgAL immunoglobulins without expression of CD 10, CD5, and CD23 antigens. The lymphoma was the final development of a 6-year history of a monoclonal lgAL increase complicated by severe renal failure due to membranoproliferative glomerulonephritis. The clinical, histological, immunologic, and cytogenetic features of this patient are very similar to those observed in the five other patients with t( I I; 18) reported to date. This translocation therefore seems to delineate a new subtype of diffuse small B-cell lymphoma with involvement of mucosal sites. Involvement of the BCU oncogene on I8q2 I could not be detected using molecular techniques with 5' as well as 3' BCU probes, indicating that other, so far unknown, genes relevant to lymphoid differentiation could be located in 18q21 and I lq21. Genes Chrom Cancer 7.5446.